Page 185 - 《环境工程技术学报》2022年第5期

Vol.12，No.5 环 境 工 程 技 术 学 报 第 12 卷，第 5 期
Sep.，2022 Journal of Environmental Engineering Technology 2022 年 9 月

李娟，沈亮，王良杰，等.基 于 AHP-FC 模型的制药行业清洁生产技术评 价 [J].环境工程技术学报，2022，12（5）：1541-1547.
E
LI J,SHEN L,WANG L J,et al.Evaluation of cleaner production technologies in pharmaceutical industry based on AHP-FCE model[J].Journal of
Environmental Engineering Technology，2022，12（5）：1541-1547.

基 于 AHP-FC 模型的制药行业清洁生产技术评价
E

1
2
1
1
1
李娟 ，沈亮 ，王良杰 ，黄晶琳 ，钱锋 ，曾萍 ，王辉锋 ，王晨昊 3
2
1*
1.中国环境科学研究院
2.厦门大学化学化工学院
3.中船第九设计研究院工程有限公司
摘要 在制药行业推行清洁生产技术，从源头减少污染物的产生，有利于促进制药行业的健康、可持续发展。为正确选择适合
的制药行业清洁生产技术，建立了包含技术、经济和环境指标的制药行业清洁生产技术评价指标体系，构建了层次分析法-模糊
综合评价法（AHP-FCE）评价模型，确定了制药行业清洁生产技术的评价标准，并 对 4 项制药行业清洁生产技术进行了综合评
价。结果表明：在技术性能方面表现较优的是头孢氨苄酶法合成技术，在经济性能方面表现较优的是抗生素合成固定化酶规模
化制备技术，在环境性能方面表现较优的是基于培养基替代的青霉素发酵减排技术；技术综合得分表明，头孢氨苄酶法合成技术
是 4 项制药行业清洁生产技术中的最优技术。
关键词 制药行业；清洁生产；层次分析法；模糊综合评价法；评价模型
中图分类号：X506 文章编号：1674-991X（2022）05-1541-07 doi：10.12153/j.issn.1674-991X.20210218

Evaluation of cleaner production technologies in pharmaceutical
industry based on AHP-FCE model

2
2
1
1
1
1*
LI Juan , SHEN Liang , WANG Liangjie , HUANG Jinglin , QIAN Feng , ZENG Ping ,
1
WANG Huifeng , WANG Chenhao 3
1.Chinese Research Academy of Environmental Sciences
2.College of Chemistry and Chemical Engineering, Xiamen University
3.China Shipbuilding NDRI Engineering Co., Ltd.
Abstract The implementation of cleaner production technologies in the pharmaceutical industry can reduce the
generation of pollutants from the source, which is conducive to promoting the healthy and sustainable development
of the pharmaceutical industry. In order to correctly select the appropriate cleaner production technologies in the
pharmaceutical industry, the evaluation index system of cleaner production technologies in the pharmaceutical
industry including technical, economic and environmental indexes was established, and the analytic hierarchy
process-fuzzy comprehensive evaluation (AHP-FCE) model was constructed. The evaluation standard of cleaner
production technologies in the pharmaceutical industry was determined, and the comprehensive evaluation of four
cleaner production technologies in the pharmaceutical industry was carried out based on the AHP-FCE model. The
results showed that cephalexin enzymatic synthesis technology was better in technical performance, large-scale
preparation technology of immobilized enzyme for antibiotic synthesis was better in economic performance, and
penicillin fermentation and emission reduction technology based on medium substitution was better in
environmental performance. The comprehensive evaluation results showed that cephalexin enzymatic synthesis
technology was the best technology in four cleaner production technologies in pharmaceutical industry.
Key words pharmaceutical industry; cleaner production; analytic hierarchy process; fuzzy comprehensive
evaluation; evaluation model

收稿日期：2021-06-08
基金项目：厦门大学大学生创新创业训练计划项目（S202010384797）；中国博士后科学基金资助项目（2019M650798）
作者简介：李娟（1988—），女，助理研究员，博士，主要从事水污染控制技术研究，lij2007@126.com
* 责任作者：曾萍（1971—），女，研究员，博士，主要从事工业废水污染控制研究，zengping@craes.org.cn